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Author: Admin | 2025-04-28
Therapy.Hemorrhage included all terms containing hematoma, hemorrhage, and hemorrhagic, and related terms indicative of bleeding including: epistaxis, hematuria, conjunctival hemorrhage, hematoma, rectal hemorrhage, periorbital hemorrhage, mouth hemorrhage, postprocedural hemorrhage, hemoptysis, skin hemorrhage, hemorrhoidal hemorrhage, ear hemorrhage, eye hemorrhage, hemorrhagic diathesis, periorbital hematoma, subdural hemorrhage, wound hemorrhage, gastric hemorrhage, lower gastrointestinal hemorrhage, spontaneous hematoma, traumatic hematoma, traumatic intracranial hemorrhage, tumor hemorrhage, retinal hemorrhage, hematochezia, hemorrhagic diarrhea, hemorrhage, melena, postprocedural hematoma, subdural hematoma, anal hemorrhage, hemorrhagic disorder, pericardial hemorrhage, postmenopausal hemorrhage, stoma site hemorrhage, subarachnoid hemorrhage, urinary tract hemorrhage, pulmonary hematoma, subcutaneous hematoma, gingival bleeding, and upper gastrointestinal hemorrhage.Major hemorrhage (defined as grade 3 or higher hemorrhage or central nervous system hemorrhage of any grade) was reported in 5% of patients.HepaticVery common (10% or more): Increased ALT (up to 30%), increased bilirubin (up to 26%), increased AST (up to 12.1%)Uncommon (0.1% to 1%): Hepatitis B reactivationFrequency not reported: Drug-induced liver injury, hepatitis BMetabolicVery common (10% or more): Increased glucose (up to 55%), increased blood uric acid (up to 31%), hypokalemia (up to 14%)Uncommon (0.1% to 1%): Tumor lysis syndromeMusculoskeletalVery common (10% or more): Musculoskeletal pain (up to 45%), pain in extremity (up to 13.9%), arthralgia (up to 13%)Common (1% to 10%): Muscle spasms, back painMusculoskeletal pain included musculoskeletal pain, musculoskeletal discomfort, myalgia, back pain, arthralgia, arthritis, pain in extremity, bone pain, spinal pain, musculoskeletal chest pain, and neck pain.Nervous systemVery common (10% or more): Headache (up to 18%), dizziness (up to 13.9%)Frequency not reported: Cerebral hemorrhage, subdural hemorrhage, peripheral neuropathy, peripheral sensory
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