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Author: Admin | 2025-04-28
Welcome to your Mechanisms of Action Quiz 2 1. Which of the following statements about bisphosphonate’s mechanism of action is false? Bisphosphonates bind to hydroxyapatite crystals in bone matrix They are preferentially deposited under osteoblasts They inhibit osteoclasts resorptive action on bone Both B and C 2. Which of the following antibacterial drugs works by disrupting cell wall synthesis? Vancomycin Fusidic acid Linezolid Chloramphenicol 3. Polar drugs have poorer oral bioavailability compared to non-polar drugs. 4. Diltiazem and verapamil are class IV antiarrhythmic drugs – meaning they work as what? Beta blockers Potassium channel blockers Calcium channel blockers Sodium channel blockers 5. Benzodiazepines – such as diazepam and lorazepam – act by potentiating the actions of GABA, and by acting at a regulatory site linked to the GABA B receptor. 6. Carbonic anhydrase inhibitors – such as acetazolamide – work by acting at which part of the nephron? Proximal tubule Loop of Henle Distal tubule Collecting duct 7. Which of the following statements about ACE inhibitors mode of action is false? ACE inhibitors reduce release of aldosterone ACE inhibitors lead to an increase in renin secretion ACE inhibitors reduce angiotensin production None of the above 8. Drugs used in the treatment of erectile dysfunction – such as sildenafil, tadalafil and vardenafil – work by inhibiting which phosphodiesterase isoenzyme? 9. Which of the following statements about diclofenac’s mechanism of action is true? Preferentially inhibits COX-1 Preferentially inhibits COX-2 Equal inhibitory ratio of COX-1 : COX-2 None of the above 10. Which of the following drugs is a dopamine receptor antagonist which enhances gastric motility, increases the rate of gastric emptying, and increases the lower gastro-oesophageal sphincter tone? Metoclopramide Misoprostol Sulfinpyrazone Granisetron
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